Karolinska Institute, Sweden invites online Application for number of Fully Funded PhD Degree at various Departments. We are providing a list of Fully Funded PhD Programs available at Karolinska Institute, Sweden.
Eligible candidate may Apply as soon as possible.
(01) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in Epidemiology
The doctoral student project aims at generating new knowledge about the impact of small-area deprivation on inequality in health. The student will investigate the spatial distribution of disease burden by small-area deprivation across regions in Sweden and explore if the socioeconomic standard of living areas can impact the health outcomes of its inhabitants. The project will build upon nationwide register data on health, health care and welfare and methods developed in the Global burden of Disease (GBD) study. The goal is to improve the knowledge around the impact of small-area deprivation and inequality in health and to help support policy decision and targeted action.
Deadline : 01.Mar.2022
(02) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in Adipocyte Systems Biology
We are seeking a highly motivated and ambitious PhD student to join the research group of Drs. Mikael Rydén (co-supervisor) and Niklas Mejhert (main supervisor) at the Department of Medicine, Huddinge. The project will be performed in collaboration with Dr. Patrik Ståhl (co-supervisor) who leads a laboratory at KTH Royal Institute of Technology which is world-leading in spatial mapping approaches. Together, we will determine how the cellular landscape and microarchitecture of white adipose tissue is affected in health and disease. The studies are based on integrative analyses of single-cell, single-nucleus and spatial transcriptomic data and the results will followed-up in different cell culture systems of human adipocytes. Most of the work will be carried out in the Rydén and Mejhert laboratory in the NEO research building at Karolinska Institutet Campus Flemingsberg.
Deadline : 23.Mar.2022
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(03) PhD Degree – Fully Funded
PhD position summary/title: PhD position in Neuroimaging and Deep Learning in Alzheimer’s Disease
In this research project, the student is expected to apply methods based on deep neural networks to identify the anatomical and functional brain connections that are most vulnerable to Alzheimer’s disease and assess whether they can predict cognitive decline. The student will also have the opportunity to learn and apply computational models to identify the mechanisms responsible for the damage of brain connections in AD. Finally, the student will include the methods developed in this project in the second version of our software (BRAPH), which will soon be released.
Deadline : 15.Mar.2022
(04) PhD Degree – Fully Funded
PhD position summary/title: Doctoral student (PhD) position in oesophageal cancer
The PhD project will examine factors that may prevent adenocarcinoma of the oesophagus, a cancer with increasing incidence and poor prognosis. In large-scale studies, based on merged data from several national health data registries in Nordic countries, the project aims to evaluate if the risk of oesophageal adenocarcinoma is decreased after obesity surgery, antireflux surgery and use of certain potentially anti-carcinogenic medications, i.e. aspirins, statins, and proton pump inhibitors.
Deadline : 14.Mar.2022
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(05) PhD Degree – Fully Funded
PhD position summary/title: Two doctoral (PhD) student positions in translational medicine & chemical biology
Project 1: OGG1 activators and inhibitors in control of inflammatory diseases
With Professor Thomas Helleday as principal supervisor, supported by Christina Kalderén, Team Leader Oliver Mortusewicz and Assistant Professor Maurice Michel in the co-supervision team, this project aims to understand both positive and negative small molecule modulation in DNA repair. In the past, we have developed OGG1 inhibitors and broadly studied the compounds from basic biochemistry and biology to first disease models (Visnes et al. 2018, Science; Visnes et al. 2020; NAR; Tanner et al. 2021, biorxiv). Currently, we are investigating small molecule activators of OGG1, as a novel technology to enhance oxidative DNA damage repair (Michel et al. 2022, unpublished). The prospective doctoral student will perform research to i) understand the precise mode of action of small molecule activators of OGG1, ii) unite research on inhibitors and activators to elucidate the molecular role of OGG1 in promoting transcription, and iii) use OGG1 inhibitors to evaluate therapeutic opportunities in a disease model of rheumatoid arthritis.
Project 2: Understanding and exploiting drug resistance in cancer – targeting SAMHD1
With Assistant Professor Sean Rudd as principal supervisor, supported by Professor Thomas Helleday and Dr Si Min Zhang in the co-supervisory team, this project seeks to understand and exploit drug resistance pathways in cancer cells. Central to this work is our previous research upon the enzyme SAMHD1 which we established as a targetable chemoresistance factor in acute myeloid leukaemia (Herold et al., 2017, Nat Med; Rudd et al., 2020, EMBO Mol Med). The doctoral student will build upon these findings and broadly aim to define and exploit this role of SAMHD1. This will entail, (i), the systematic characterisation of the interaction of SAMHD1 with nucleoside drugs, (ii) the development and benchmarking of small molecule SAMHD1 inhibitors, and (iii), defining the broader role of SAMHD1 in modulating the efficacy of oncology drugs.
Deadline : 11.Mar.2022
(06) PhD Degree – Fully Funded
PhD position summary/title: Doctoral student position in Synthetic biology for targeting glioblastoma
The main project is to create solid lipid nanoparticles (SLNs) to be used as transfection vectors for transfection of glioblastoma (GBM) cell lines, GBM organoids and murine animal xenotransplantation models. The long-term goal is to develop vectors that specifically target and eliminate GBM cells
Deadline : 11.Mar.2022
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(07) PhD Degree – Fully Funded
PhD position summary/title: Two doctoral (PhD) student positions in translational medicine & chemical biology
The laboratory of Professor Thomas Helleday and the research group of Assistant Professor Sean Rudd is seeking to recruit two highly motivated and enthusiastic doctoral (PhD) students for independent projects on improving treatments for inflammatory diseases and cancer, respectively. The Helleday and Rudd groups are affiliated with the Department of Oncology-Pathology at Karolinska Institutet and are co-located at SciLifeLab, a national centre for molecular biosciences containing state-of-the-art high-throughput technology platforms together with world-leading research labs.
Deadline : 11.Mar.2022
(08) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in liquid biopsy biomarkers of pancreatic beta cell damage
This KID-funded Ph.D. project focuses on developing non-invasive methods for identifying individuals at risk of type 1 diabetes and as such will contribute to the introduction of personalized medicines for use in preventing this common and life-threatening disease. More specifically, the candidate will contribute to the discovery of protein biomarkers that predict disease onset. The candidate will be part of a supportive team and in this environment, perform global proteomics analyses of the secretome and extracellular vesicles released from cultured cells. The candidate will also contribute to the identification of biomarkers in whole plasma samples and plasma-derived extracellular vesicles collected from an experimental model of type 1 diabetes. The tasks include learning and performing methods for extracting and characterizing extracellular vesicles including nanoparticle tracking analysis, electron microscopy (EM), methods for identifying secreted and extracellular vesicle associated proteins including advanced mass spectrometry (conducted by SciLifeLab), Western blot, etc. It may also include work with experimental disease models and viruses suspected to play a role in triggering type 1 diabetes. The work is performed in the Flodström-Tullberg group with extra support for the studies involving extracellular vesicles provided by the co-supervisor, Samir el Andaloussi and his team. The student will learn how to handle the necessary bioinformatics tools and software for data analysis (proteomics), with guidance from a member of the main supervisor’s laboratory and NBIS (https://nbis.se).
Deadline : 09.Mar.2022
(09) PhD Degree – Fully Funded
PhD position summary/title: Doktorandplats inom tyreoideacancer och livskvalitet
Forskargruppen inom tyreoideacancer bedriver forskning om vilka långtidseffekter tyreoideacancer har på livskvalitet och symtom. Inom gruppen får du en unik möjlighet att arbeta tätt tillsammans med experter inom onkologi, palliativ medicin och psykologi för att hitta orsaker till de symtom som patienter uppger efter en cancerdiagnos och också delta i utvecklingen av nya behandlingsmetoder för att minska de psykologiska effekterna.
Deadline : 2022-03-06
(10) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in experimental oncology
The doctoral Programme is a collaboration between the Karolinska Institutet and KTH Royal Institute of Technology, aiming towards a joint doctoral degree. (https://staff.ki.se/rules-and-routines-for-the-joint-doctoral-programme-in-medical-technology ).This project is entitled “Molecular sex differences and estrogen receptor beta impact colorectal cancer development”. Colorectal cancer is the 3rd most common cancer for men and women, but a truly preventive or targeted therapy against this disease does not yet exist. Estrogen is associated with a lower incidence and our goal is to understand the basic mechanistic background of this association. Estrogen signaling is mediated by estrogen receptors which can be activated or inactivated by ligands, and are ideal candidates for therapeutic targeting.
Deadline : 04.Mar.2022
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(11) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in Neuronal Networks and Cognitive Deficits
The PhD student will perform electrophysiological analyses of the brain circuitry in the animal models used. Electrophysiology provides the foundation of the project, complemented with other methods to elucidate the roles of excitatory and inhibitory neuronal populations. These include immunohistochemistry, immunodetection of specific proteins in tissue extracts or blood, single-cell RNA sequencing, bioinformatics, and cell culture.
Deadline : 03.Mar.2022
(12) PhD Degree – Fully Funded
PhD position summary/title: Doktorandplats med delfinansiering (KID-anslag) inom medicinsk vetenskap med inriktning på feokromocytom
Institutionen för onkologi-patologi utlyser en doktorandplats inom Catharina Larsson forskargrupp. Gruppen arbetar med vetenskapliga frågeställningar avseende endokrina tumörer bl.a. i binjurar och sköldkörtel. Arbetet omfattar identifiering av förvärvade och ärftliga genetiska, och andra molekylära förändringar involverade vid tumöruppkomst och progression samt dessas molekylära konsekvenser, betydelse för det kliniska förloppet och behandling. Forskningen förväntas bidra till ökad sjukdomsförståelse och ge kliniskt applicerbara resultat.
Deadline : 2022-03-03
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(13) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in Cardiovascular immunology
The successful applicant will work together with other scientists in the group and perform mechanistic studies of adaptive immune reactions in atherosclerosis. Your mission will be to identify responses evoked by LDL-reactive T cells that regulate lipoprotein metabolism and atherosclerosis. This will include the study of genetically modified mice and human biobank material. Specific immune responses, metabolic effects, and atherosclerotic plaque morphometrics are key readouts. Experiments will commonly involve cell culture, flow cytometry, RNA sequencing, molecular cloning with bacteria, and immunochemical techniques. The successful candidate is expected to work closely with other members of the research group, contribute significantly to a productive research environment, and obtain training in the doctoral program for cardiovascular research.
Deadline : 02.Mar.2022
(14) PhD Degree – Fully Funded
PhD position summary/title: Doctoral (PhD) student position in Cardiovascular immunology
The successful applicant will work together with other scientists in the group and perform mechanistic studies of adaptive immune reactions in atherosclerosis. Your mission will be to identify responses evoked by LDL-reactive T cells that regulate lipoprotein metabolism and atherosclerosis. This will include the study of genetically modified mice and human biobank material. Specific immune responses, metabolic effects, and atherosclerotic plaque morphometrics are key readouts. Experiments will commonly involve cell culture, flow cytometry, RNA sequencing, molecular cloning with bacteria, and immunochemical techniques. The successful candidate is expected to work closely with other members of the research group, contribute significantly to a productive research environment, and obtain training in the doctoral program for cardiovascular research.
Deadline : 02.Mar.2022
About The Karolinska Institute, Sweden – Official Website
The Karolinska Institute sometimes known as the (Royal) Caroline Institute in English is a research-led medical university in Solna within the Stockholm urban area of Sweden. The Nobel Assembly at the Karolinska Institute awards the Nobel Prize in Physiology or Medicine. The assembly consists of fifty professors from various medical disciplines at the university. The current rector of Karolinska Institute is Ole Petter Ottersen, who took office in August 2017.
The Karolinska Institute was founded in 1810 on the island of Kungsholmen on the west side of Stockholm; the main campus was relocated decades later to Solna, just outside Stockholm. A second campus was established more recently in Flemingsberg, Huddinge, south of Stockholm.
The Karolinska Institute is Sweden’s third oldest medical school, after Uppsala University (founded in 1477) and Lund University (founded in 1666). It is one of Sweden’s largest centres for training and research, accounting for 30% of the medical training and more than 40% of all academic medical and life science research conducted in Sweden.
The Karolinska University Hospital, located in Solna and Huddinge, is associated with the university as a research and teaching hospital. Together they form an academic health science centre. While most of the medical programs are taught in Swedish, the bulk of the PhD projects are conducted in English. The institute’s name is a reference to the Caroleans.
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