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29 Postdoctoral Position at The University of Pennsylvania, USA

29 Postdoctoral Position at The University of Pennsylvania, USA

The University of Pennsylvania, United States invites online Application for various Postdoctoral Position in their different Departments. We are providing a list of Postdoc positions available at The University of Pennsylvania, Pennsylvania, United States.

Eligible candidate may Apply as soon as possible.

 

(01) Postdoctoral Position

Postdoctoral position summary/title: Cancer Biology-Basic Sciences Dept

Laboratory led by Dr. Donita Brady in the Department of Cancer Biology at the Perelman School of Medicine and Abramson Family Cancer Research Institute at the University of Pennsylvania is seeking two highly motivated and organized Postdoctoral Fellow. The research interests of our laboratory lie at the intersection of cancer biology, signal transduction, and metal homeostasis.

The ideal candidate will be self-motivated, enthusiastic, talented, and interested in leading a project aimed at unraveling the complete framework of metal integration into signaling networks during normal physiology and in the context of tumorigenesis. This position offers the opportunity to contribute to the foundation of a new area of research in our lab that leverages chemical biology to understand metal protein interactions and understand the interplay between subcellular compartments of metal homeostasis on signal transduction, to participate in a dynamic research environment, gain exposure to a innovative and collegial research community within the Department of Cancer Biology and AFRCI, and mentoring necessary to develop into an independent researcher.

Deadline of Postdoc Position: Open until Filled

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(02) Postdoctoral Position

Postdoctoral position summary/title: Cancer Biology-Basic Sciences Dept

Two postdoctoral positions are available in the laboratory of Dr. Xiaolu Yang at the Perelman School of Medicine at the University of Pennsylvania. Our lab is interested in the biology and therapy of cancer and neurodegenerative diseases. Our current projects focus on two areas:

(1) The tumor suppressor p53, metabolism, and autophagy We are interested in the regulation and functions of the preeminent tumor suppressor p53. Our recent results revealed an important role for p53 in modulating metabolic pathways for biosynthesis and redox balance. We are investigating the function of p53 as both a sentinel and a regulator for various metabolic activities. We are also studying metabolic alterations that drive tumor initiation and progression. A recent extension of this research area is to define the role of metabolism and autophagy in stem cells, including embryonic stem cells and cancer stem cells.

(2) Protein quality control (PQC) and neurodegenerative disease. Our lab recently identified a novel protein quality control (PQC) system in animal cells that is mechanistically distinct from canonical PQC systems and is highly effective in suppressing protein misfolding and aggregation. We are investigating the mechanism of action of this system and its role in aging and neurodegenerative diseases including Alzheimer’s disease, Parkinson’s disease, ALS, and polyglutamine diseases. We are also developing novel therapies based on this system to treat neurodegenerative diseases.

Deadline of Postdoc Position: Open until Filled

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(03) Postdoctoral Position

Postdoctoral position summary/title: Bacteriology

A postdoctoral position is available immediately in Zhu laboratory in the Microbiology Department of the School of Medicine. We are studying pathogen-host-microbiome interaction and antibiotic resistance mechanisms, including Vibrio cholerae and multi-drug resistant enterobacteria.

Deadline of Postdoc Position: Open until Filled

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(04) Postdoctoral Position

Postdoctoral position summary/title: Pulmonary, Allergy and Critical Care

The Laboratory of Rare Lung Diseases at PENN/CHOP Lung Biology Institute at the University of Pennsylvania Perelman School of Medicine is seeking a talented, self-motivated individual to participate in lung disease research to study age- and sex-dependent lung damage with specific focus on the role of TSC2-dependent mTORC1 activation and WNT signaling involving exocytic trafficking. Under the guidance of Dr. Vera Krymskaya (https://www.med.upenn.edu/apps/faculty/index.php/g275/p8114) and Dr. Wei Guo (https://www.bio.upenn.edu/people/wei-guo), the successful applicant will be part of an interdisciplinary team to determine how mTORC1 hyperactivation dysregulates mTORC1-WNT signaling crosstalk with a major focus will be on interrogating molecular basis of Wnt ligands exocytosis functioning in the concert with cytoskeleton, their effect on chronic activation of resident mesenchymal and alveolar epithelial cells and how it drives cystic lung destruction. The translational studies will be focused on dampening hyperactive mTORC1 and WNT signaling to basal physiological levels as a potential translational opportunity to enhance the efficacy of rapalogs and potentially provide novel adjuvant therapy for diseases associated with mTOR and WNT hyperactivation.

Deadline of Postdoc Position: Open until Filled

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(05) Postdoctoral Position

Postdoctoral position summary/title: Cell and Developmental Biology

The Bi lab is seeking two highly motivated postdocs, starting on July 1st, 2021, to conduct research on the mechanisms of hepatocyte polarization and apical tube formation using a rat hepatocyte cell line. The same problems will be addressed in parallel using the mouse model by an outstanding collaborator. The newly recruited postdocs will work in a highly supportive and interactive environment with others who study the mechanisms of cytokinesis and septin assembly and remodeling using both budding yeast and mammalian cells as the experimental systems. All the questions in the Bi lab have been addressed using an integrative approach that combines gene editing, advanced imaging, and biochemical analysis

Deadline of Postdoc Position: Open until Filled

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(06) Postdoctoral Position

Postdoctoral position summary/title: Center for Sleep and Circadian Neurobiology

The Anafi lab is looking to recruit a postdoctoral fellow. The lab is based in the Department of Medicine and is part of the Penn Institute for Biomedical Informatics and the Chronobiology and Sleep Institute.

The lab focuses on understanding the influence of sleep and
circadian rhythms on physiology and disease using techniques from engineering, bioinformatics, and machine learning.

Ongoing, NIH funded projects are concentrated on understanding circadian pathways in cancer and neurodegeneration. Collaborative projects combine computational analysis with experiments to identify new diagnostic tools and/or rational targets for chronotherapy.

Deadline of Postdoc Position: Open until Filled

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(07) Postdoctoral Position

Postdoctoral position summary/title: DM-Hematology/Oncology Cancer Biology

The Babushok laboratory at the University of Pennsylvania aims to understand the pathogenic mechanisms of immune-mediated bone marrow failure diseases and to elucidate drivers of pre-malignant clonal evolution in bone marrow failure disorders. The long-term goal of the laboratory is to transform the improved understanding of autoimmune pathogenesis of bone marrow failure into the improved diagnosis and treatment of these life-threatening diseases. The laboratory seeks a creative and dedicated Post-Doctoral Fellow to join our team to study the mechanisms of immune-mediated marrow failure.

Deadline of Postdoc Position: Open until Filled

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(08) Postdoctoral Position

Postdoctoral position summary/title: Dermatology

A postdoctoral position is available in the Department of Dermatology to develop a novel field of engineered cellular immunotherapies for the treatment of B cell-mediated autoimmune diseases, including renal and neurologic diseases. The position will provide unique experience in the preclinical development of first-in-human cellular immunotherapies, including collaboration with industry partners. Please send a curriculum vitae, a brief cover letter summarizing current research and career goals, and the names and contact information of three references to: Aimee S. Payne, M.D., Ph.D., Department of Dermatology; Email: aimee.payne@pennmedicine.upenn.edu.

Deadline of Postdoc Position: Open until Filled

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(09) Postdoctoral Position

Postdoctoral position summary/title: Genetics

We are searching for 2 postdoctoral researchers to work on projects in the areas of human population genetics, evolution and disease genetics. Some ongoing projects in the lab are below, but we are very open to other research projects in our broad area of interest.

1) Using ancient DNA to detect selection on complex traits. Developing methods to detect selection using ancient DNA. Understanding the role of polygenic adaptation in human evolution. Integrating genetic, archaeological and anthropological data.

2) Understanding the use and transferability of polygenic risk scores. Why do PRS not transfer across populations? Can we improve on the design of PRS? How do population structure, selection and demographic history affect PRS?

Deadline of Postdoc Position: Open until Filled

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(10) Postdoctoral Position

Postdoctoral position summary/title: Genetics

POSTDOCTORAL POSITION (NIH-funded) available to study drivers of hepatocellular carcinoma (HCC) using advanced mouse genetics, massively parallel in vivo Crisr/Cas9 screens, and state-of-the-art genomic approaches.

Deadline of Postdoc Position: Open until Filled

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(11) Postdoctoral Position

Postdoctoral position summary/title: Genetics

POSTDOCTORAL POSITION (NIH-funded) available to study drivers of hepatocellular carcinoma (HCC) using advanced mouse genetics, massively parallel in vivo Crisr/Cas9 screens, and state-of-the-art genomic approaches.

Deadline of Postdoc Position: Open until Filled

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(12) Postdoctoral Position

Postdoctoral position summary/title: Genetics

POSTDOCTORAL POSITION (NIH-funded) available to study drivers of hepatocellular carcinoma (HCC) using advanced mouse genetics, massively parallel in vivo Crisr/Cas9 screens, and state-of-the-art genomic approaches

Deadline of Postdoc Position: Open until Filled

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(13) Postdoctoral Position

Postdoctoral position summary/title: Microbiology

A postdoctoral fellow position is available in Dr. Michael Abt’s lab in the Department of Microbiology at the University of Pennsylvania. We are seeking a highly motivated, independent, and collaborative scientist to study immune mechanisms supporting microbiome-based therapeutics to expand upon recent findings published by our group (Littmann ER et. al. Nat. Commun. 2021). The position is federally supported by a recently awarded NIH-NIAID R01 grant. Our research group studies interactions between the host immune system and the intestinal microbiome in the context of infectious disease using the latest immunologic, microbiologic and next-generation sequencing technologies.

Deadline of Postdoc Position: Open until Filled

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(14) Postdoctoral Position

Postdoctoral position summary/title: Neurosurgery

The researcher will assist the Principal Investigator to complete critical tasks including clinical and preclinical research. The postdoctoral researcher will help building and maintaining a neurovascular tissue database from surgically resected specimens for different research projects within the Lab. He will also assist the PI in clinical research projects and will have insights into the role of a neurosurgeon-scientist. In addition to the mentorship from the PI, the researcher will be supported and mentored by a senior research investigator in the Burkhardt Lab and will provide guidance and support him-/herself to rotating medical students in the lab. The candidate will serve as lead on own projects, as well as assisting in other projects. Travel to conferences/presentation is possible if desired, but not necessary.

Deadline of Postdoc Position: Open until Filled

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(15) Postdoctoral Position

Postdoctoral position summary/title: Obstetrics and Gynecology

Two postdoctoral researcher positions are available immediately. The positions will be supported by grants from National Cancer Institute as well as non-federal research grants. The projects will focus on 1) epigenetic alteration and non-coding RNAs; 2) tumor immunology and adoptive T cell therapy; and 3) targeted and epigenetic therapy. Next generation sequencing, single cell analysis, knockout and transgenic animals and gene editing technologies will be used in these projects. Novel computational biology approaches and resources will be provided from our computational biology team in the lab (http://52.25.87.215/home/). The position requires experience in cellular and molecular biology, such as the experimental technology on molecular mechanisms that control malignant transformation, tumor progression and metastasis. Previous experience in tumor immunology, knock-out and transgenic animals, RNA biology, epigenetics, cancer biology and cancer genomics would be helpful. We are also welcome the candidates, who are trained in other fields such as developmental biology, genetics and genomics, to apply these positions.

Deadline of Postdoc Position: Open until Filled

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(16) Postdoctoral Position

Postdoctoral position summary/title: Ophthalmology

The Uyhazi and Bennett laboratories at the University of Pennsylvania are seeking a motivated postdoctoral fellow to join our team to investigate gene therapy and cell-based therapies for vision loss. Our goal is to use cutting-edge technology focused on photoreceptor regeneration to better understand the cellular and molecular biology of retinal degeneration and to develop novel therapies for blinding diseases. The ideal candidate will have a Ph.D., M.D., or both with experience in genetic mouse models, molecular biology, immunofluorescence staining, and microscopy. Additional experience in single cell data analysis, iPSC culture, and visual function testing is an asset. Candidates should be willing to work in a team environment that is enthusiastic, collaborative, and supportive.

Deadline of Postdoc Position: Open until Filled

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(17) Postdoctoral Position

Postdoctoral position summary/title: Orthopaedic Surgery

The department of Orthopaedic Surgery at the University of Pennsylvania, School of Medicine in Philadelphia is seeking exceptional candidates to fill a postdoctoral position in the laboratory of Dr. Foteini Mourkioti. The Mourkioti laboratory is interested in the fundamental aspects of how skeletal muscles and cardiac systems function as well as the practical aspects of manipulating these systems by using animal models and tissue engineering approaches for disease intervention. The experiments will include mouse work, surgical procedures, flow cytometry, cell culture, histological and live-imaging methods.

Deadline of Postdoc Position: Open until Filled

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(18) Postdoctoral Position

Postdoctoral position summary/title: Orthopaedic Surgery

A postdoctoral position is available in the Department of Orthopaedic Surgery at the Perelman School of Medicine, University of Pennsylvania, to study stem cells in skeletal development and diseases.
We take advantage of multi-disciplinary approaches including advanced single cell transcriptomics, sophisticated genetical mouse models and surgery-induced disease models, and cutting-edge three dimensional imaging, to identify mesenchymal subpopulations in bone and joint tissues and to understand their functions and regulatory mechanisms under physiological and pathological conditions. UPenn is a highly collaborative environment. We are currently collaborating with multiple other research laboratories specializing in nanomaterial, biomechanics, tissue engineering, adipose biology, and bioinformatics with a goal of translating our projects into future clinical applications. Several exciting projects are available for the candidate to choose from, covering the areas of bone remodeling, marrow adipocytes, joint biology, and tissue regeneration. Please refer to our recent publications (Single cell transcriptomics identifies a unique adipose lineage cell population that regulates bone marrow environment. Elife e54695; MALPs promote osteoclastogenesis in bone remodeling and pathologic bone loss. J Clin Invest. JCI e140214; Targeting cartilage EGFR pathway for osteoarthritis treatment.

Deadline of Postdoc Position: Open until Filled

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(19) Postdoctoral Position

Postdoctoral position summary/title: Orthopaedic Surgery

The department of Orthopaedic Surgery at the University of Pennsylvania, School of Medicine in Philadelphia is seeking exceptional candidates to fill a postdoctoral position in the Human Motion Lab directed by Dr. Josh Baxter. The Human Motion Lab is focused on translational research leveraging wearable technology, ultrasound imaging, motion capture techniques, and computational modeling to investigate musculoskeletal injuries and treatments.
The position provides the opportunity for extensive interdisciplinary interactions with researchers at Penn and University of Delaware working in areas including orthopaedic surgery, physical therapy, image processing, machine learning, and statistical modeling. The Human Motion Lab has strong collaborative ties with the McKay Orthopaedic Research Laboratory and the successful applicant will have the opportunity to take advantage of professional and scientific programming.

Deadline of Postdoc Position: Open until Filled

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(20) Postdoctoral Position

Postdoctoral position summary/title: Pediatrics

We are seeking a self-motivated and enthusiastic candidate for a postdoctoral scholar position. The postdoc will participate in an exciting project that uses various single-cell technologies to understand tumor clonal evolution, transcriptional and epigenetic heterogeneity and signaling within the tumor microenvironment, during standard and immuno therapeutic responses. The project is funded by a recent NCI center grant to establish the center for pediatric tumor cell atlas as part of the Moonshot initiative (https://humantumoratlas.org/). The project provides an excellent training opportunity in single cell biology and cancer biology.

Deadline of Postdoc Position: Open until Filled

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(21) Postdoctoral Position

Postdoctoral position summary/title: Pediatrics

The Tan research group is interdisciplinary and highly collaborative, utilizing both computational and experimental approaches to study gene regulation. We have pioneered multiple computational algorithms for regulatory genomics, epigenomics, and network biology. Specific projects will be defined by the candidates (and based on the candidates expertise) and with input from Dr. Tan and our close collaborators at the Center for Childhood Cancer Research CHOP and Abramson Cancer Center at the University of Pennsylvania.

The postdoctoral fellow will be responsible for development of novel computational algorithms and/or experimental approaches to understand gene regulation in normal and cancer development. Specifical research areas include:

1. Regulatory genomics. Focusing on generating insights into how mutations in regulatory DNA sequences contribute to development and oncogenesis.
2. Cancer systems biology. Focusing on generating insights into the relationship between the dynamics of gene networks during cancer development.
3. Algorithms for single-cell analysis. Focusing developing statistical methods for analyzing single-cell transcriptome and epigenome data.

Deadline of Postdoc Position: Open until Filled

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(22) Postdoctoral Position

Postdoctoral position summary/title: Pharmacology

The Thomas lab has several research positions open to senior PhD students, postdocs and other researchers holding PhDs in neuroscience or related fields. These positions are for taking the lead on projects in the lab that examine neuromodulatory signaling in cognition, with an emphasis on learning and memory in the hippocampus. Results from these studies will enhance our understanding of how memory is affected by acute stress, by neurodegenerative diseases such as Alzheimer’s and Parkinson’s, and by neuropsychiatric disorders that include post-traumatic stress and depression, as well as inform potential therapeutic avenues in these areas. Toward these goals, the lab utilizes mouse genetics, neuropharmacology, chemo- and optogenetics, viral transduction, electrophysiology, imaging and biochemical approaches.

Deadline of Postdoc Position: Open until Filled

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(23) Postdoctoral Position

Postdoctoral position summary/title: Physiology

Postdoctoral positions to study the molecular physiologies of InsP3R and MCU Ca2+ ion channels and CALHM ion channels are available in the laboratory of Kevin Foskett at the Perelman School of Medicine of the University of Pennsylvania in Philadelphia, Pennsylvania.

Deadline of Postdoc Position: Open until Filled

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(24) Postdoctoral Position

Postdoctoral position summary/title: Physiology

A postdoctoral fellowship position is available in the lab of Dr. Kevin Foskett in the Department of Physiology in the Perelman School of Medicine to investigate signaling mechanisms in intestinal tuft cells. Tuft cells are immune sentinels in the gut that orchestrate a type 2 innate lymphoid cell-epithelial response circuit, by pathogen-induced interleukin-25 (IL-25) secretion that mediates host defense against parasitic infections and other pathogenic and inflammatory stimuli. The signal transduction mechanisms in these cells are unknown despite their physiological importance.

Deadline of Postdoc Position: Open until Filled

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(25) Postdoctoral Position

Postdoctoral position summary/title: Psychiatry

The Center for Studies of Addiction in the Department of Psychiatry at the University of Pennsylvania is seeking applications for a post-doctoral research position. Our current work focuses on understanding the genetic underpinnings of substance use and comorbid psychiatric disorders using genetic and phenotypic data from electronic health records with linked biobanks. We are leading a number of genomics studies of substance use disorders, including two in the Million Veteran Program, a large dataset of over 850,000 veterans with genetic data currently available for 650,000 individuals. We also have access to genetic and phenotypic data from the Penn Medicine Biobank, which includes 65,000 patients, and the Yale-Penn study, which includes 12,000 individuals with an in-depth substance use and psychiatric assessment

Deadline of Postdoc Position: Open until Filled

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(26) Postdoctoral Position

Postdoctoral position summary/title: Biostatistics and Epidemiology

The SemAnTICA (Semantic Analysis of Text for Informing Clinical Action) Lab, housed in the Department of Biostatistics, Epidemiology, & Informatics (DBEI), is led by Danielle Mowery PhD, Assistant Professor of Informatics at the University of Pennsylvania and Chief Research Information Officer of Penn Medicine through the Institute for Biomedical Informatics (IBI). Our mission is to develop technologies, primarily natural language processing (NLP) solutions, which support clinical and translational research studies for improving patient care by learning and/or promoting actionable knowledge from electronic health records. We are currently seeking a postdoctoral fellow. An ideal candidate will develop novel natural language processing and computational methods for extracting study variables and defining deep phenotypes from clinical text-based resources including clinical notes, transcripts, free-texts, and more. These methods could address one or more use cases from a diverse set of clinical specialties e.g., cancer, neurology, dermatology, cardiology, etc. As a member of the SemAnTICA Lab, the candidate will primarily participate in NLP research. The candidate may also collaborate with clinical data scientists from the IBI Clinical Research Informatics Core (CIC) within the Institute for Biomedical Informatics that serve the needs of clinical investigators throughout Perelman School of Medicine.

Deadline of Postdoc Position: Open until Filled

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(27) Postdoctoral Position

Postdoctoral position summary/title: Biomedical Postdoc Progams

A postdoctoral position is immediately available at the University of Pennsylvania Perelman School of Medicine to work at the interface of cancer biology with molecular biomarker development and translational therapeutics for HPV-related head and neck cancer. This position represents an exceptional opportunity for a highly motivated individual to assume leadership of well-established, ongoing projects in the following areas:

(1) Developing prognostic and predictive molecular biomarkers for HPV-related cancer from comparative multi-omic analyses of tumors across large patient cohorts

(2) Single cell characterization of diverse tumor metabolic cell states within an HPV-related malignancy that may cooperatively contribute to therapy resistance

(3) Screening molecular dependencies unique to a subset of HPV-related cancers with poor prognosis

Deadline of Postdoc Position: Open until Filled

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(28) Postdoctoral Position

Postdoctoral position summary/title: Abramson Cancer Center

The laboratory’s research is focused on post-transcriptional gene regulation and the roles of RNA-binding proteins, modifications, and signaling that are rewired during oncogenesis and cancer progression. Current studies use biochemistry, molecular biology, cell biology, with potential for bioinformatics and mouse modeling.

Deadline of Postdoc Position: Open until Filled

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(29) Postdoctoral Position

Postdoctoral position summary/title: Biochemistry and Biophysics

A post-doctoral position is available in the laboratory of Dr. Ronen Marmorstein at the Perelman School of Medicine at the University of Pennsylvania. The Marmorstein laboratory studies the molecular mechanisms of (1) protein post- and co-translational protein acetylation and acetyl-CoA metabolism (2) gene expression and epigenetic regulation, and (3) MAPK signaling. The laboratory uses a broad range of biochemical, biophysical and structural research tools (X-ray crystallography and cryo-EM) to determine macromolecular structure and mechanism of action. The laboratory also uses high-throughput small molecule screening and structure-based design strategies to develop protein-specific small-molecule probes to interrogate protein function and for preclinical studies. 

Deadline of Postdoc Position: Open until Filled

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About The University of Pennsylvania, United States – Official Website

The University of Pennsylvania is a private Ivy League research university in Philadelphia, Pennsylvania. The university claims a founding date of 1740 and is one of the nine colonial colleges chartered prior to the U.S. Declaration of Independence. Benjamin Franklin, Penn’s founder and first president, advocated an educational program that trained leaders in commerce, government, and public service, similar to a modern liberal arts curriculum with a practical perspective.

Penn has four undergraduate schools as well as twelve graduate and professional schools. Schools enrolling undergraduates include the College of Arts and Sciences, the School of Engineering and Applied Science, the Wharton School, and the School of Nursing. Penn’s “One University Policy” allows students to enroll in classes in any of Penn’s twelve schools. Among its highly ranked graduate and professional schools are a law school whose first professor wrote the first draft of the United States Constitution, the first school of medicine in North America (Perelman School of Medicine, 1765), and the first collegiate business school (Wharton School, 1881).

 

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